LY2228820 (Ralimetinib)

Catalog No. A10545

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
Catalog Num A10545
M. Wt 612.7
Formula C24H29FN6.2CH4O3S
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 862507-23-1
Synonyms LY-2228820
SMILES CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O
LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
Targets
p38α (Cell-free assay)
7 nM
In vitro (25°C) DMSO Warmed: 4 mg/mL (6.52 mM)
Water Warmed: 91 mg/mL (148.51 mM)
Ethanol 3 mg/mL (4.89 mM)
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.32 mL 81.61 mL 163.21 mL
0.5 mM 3.26 mL 16.32 mL 32.64 mL
1 mM 1.63 mL 8.16 mL 16.32 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.