LY2784544 (Gandotinib)

Catalog No. A10546

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Catalog Num A10546
M. Wt 469.9
Formula C23H25ClFN7O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1229236-86-5
Synonyms N/A
SMILES CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Targets
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM
In vitro DMSO 94 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81 mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.