MGCD0103 (Mocetinostat)Catalog No. A10586

Quick Overview

MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.
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MGCD0103 (Mocetinostat)

MGCD0103 (Mocetinostat)  Citations(1)
  • Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
  • Product Information
    Catalog Num A10586
    M. Wt 396.4
    Formula C23H20N6O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 726169-73-9
    Synonyms MGCD-0103
    Chemical Name N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl] benzamide
    SMILES Code C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4

    Biological activity
    Introduction
    MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.
    Targets
    Target Value
    HDAC1IC50: 0.15μM
    HDAC2IC50: 0.29μM
    HDAC11IC50: 0.59μM
    HDAC3IC50: 1.66μM
    HDAC4IC50: >10μM
    HDAC5IC50: >10μM
    HDAC6IC50: >10μM
    HDAC7IC50: >10μM
    HDAC8IC50: >10μM
    Solubility
    Solubility (25C) * In vitro DMSO 13 mg/mL (32.79 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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