NVP-ADW742Catalog No. A10658

Quick Overview

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
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NVP-ADW742

NVP-ADW742  Citations(2)
  • Kazuya Takayama,et al. Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration, Sci Rep, 2018, 8: 8278 29844341
  • Kentaro Hirose,et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. 25480380
  • Product Information
    Catalog Num A10658
    M. Wt 453.6
    Formula C28H31N5O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 475488-23-4
    Synonyms NVPADW742, ADW742, ADW-742, GSK 552602A
    Chemical Name 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    SMILES Code C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

    Biological activity
    Introduction
    NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
    Targets
    IGF-1R
    0.17 μM
    Solubility
    Solubility (25C)* In vitro DMSO 10 mg/mL heating (22.04 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 3 mg/mL (6.61 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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