Perifosine (NSC-639966)Catalog No. A10709

Quick Overview

Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
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Perifosine (NSC-639966)

Perifosine (NSC-639966)  Citations(3)
  • Kyoung-Jae Won,et al. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells, Cell Death Dis, 2017, Jan; 8(1): e2554 28079882
  • Zhipeng Li,et al. A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-百B regulates head and neck squamous cell carcinoma proliferation, Oncotarget, 2016, May 31; 7(22): 31892-31906 26895469
  • Won KJ,et al. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription., Apoptosis., 2014, Jan;19(1):179-90 24085402
  • Product Information
    Catalog Num A10709
    M. Wt 461.7
    Formula C25H52NO4P
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 157716-52-4
    Synonyms KRX-0401,NSC 639966
    Chemical Name 1,1-Dimethylpiperidinium-4-yl octadecyl phosphate
    SMILES Code CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

    Biological activity
    Introduction
    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
    Targets
    Akt (MM.1S cells)
    4.7 μM
    Solubility
    Solubility (25C) * In vitro DMSO <1 mg/mL (<1 mM)
    Water 8 mg/mL (17.32 mM)
    Ethanol 15 mg/mL (32.49 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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