PF-2341066 (Crizotinib)Catalog No. A10712

Quick Overview

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
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PF-2341066 (Crizotinib)

PF-2341066 (Crizotinib)  Citations(3)
  • Li T,et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 30013190
  • Saki Omote,et al. Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1, Sci Rep, 2018, 8: 9237 29915248
  • Arakawa H,et al. Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2, J Pharm Sci, 2017, Sep;106(9):2899-2903 28336299
  • Product Information
    Catalog Num A10712
    M. Wt 450.3
    Formula C21H22Cl2FN5O
    Solubility DMSO>23mg/mL Water<1mg/mL Ethanol>8mg/mL
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 877399-52-5
    Synonyms PF02341066
    Chemical Name 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
    SMILES Code C[[email protected]](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

    Biological activity
    Introduction
    PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
    Targets
    c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells) ALK (Karpas299 cells)
    11 nM24 nM
    Solubility
    Solubility (25C) * In vitro DMSO 9 mg/mL (19.98 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 0.5% CMC Na 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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    High Purity Kinase Inhibitors on Signaling Pathways

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