PIK-75Catalog No. A10729

Quick Overview

PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
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PIK-75

PIK-75  Citations(1)
  • Pridham KJ,et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 29016844
  • Product Information
    Catalog Num A10729
    M. Wt 488.7
    Formula C16H14BrN5O4S.HCl
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 372196-77-5
    Synonyms PIK75
    Chemical Name 2-​methyl-​5-​nitro-​2-​[(6-​bromoimidazo[1,​2-​a]pyridin-​3-​yl)methylene]-​1-​methylhydrazide-​benzenesulfonic acid
    SMILES Code CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl

    Biological activity
    Introduction
    PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
    Targets
    DNA-PK (Cell-free assay) p110α (Cell-free assay) p110γ (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
    2 nM5.8 nM76 nM0.51 μM1.3 μM
    Solubility
    Solubility (25C)* In vitro DMSO 3 mg/mL (6.13 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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