PTC124 (Ataluren)Catalog No. A10758

Quick Overview

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
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PTC124 (Ataluren)

PTC124 (Ataluren)  Citations(1)
  • Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
  • Product Information
    Catalog Num A10758
    M. Wt 284.2
    Formula C15H9FN2O3
    Solubility DMSO>57mg/mL Water<1mg/mL Ethanol<1mg/mL
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 775304-57-9
    Synonyms PTC-124, PTC 124
    SMILES Code C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

    Biological activity
    Introduction
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
    Targets
    CFTR (HEK293 cells)
    Solubility
    Solubility (25C) * In vitro DMSO 57 mg/mL (200.53 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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