PTC124 (Ataluren)

Catalog No. A10758

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
  • Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
Catalog Num A10758
M. Wt 284.2
Formula C15H9FN2O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 775304-57-9
Synonyms PTC-124, PTC 124
SMILES C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
Targets
CFTR (HEK293 cells)
In vitro (25°C) DMSO 57 mg/mL (200.53 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.19 mL 175.93 mL 351.86 mL
0.5 mM 7.04 mL 35.19 mL 70.37 mL
1 mM 3.52 mL 17.59 mL 35.19 mL
5 mM 0.7 mL 3.52 mL 7.04 mL

*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.