Ramelteon (TAK-375)

Catalog No. A10777

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.
Catalog Num A10777
M. Wt 259.3
Formula C16H21NO2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 196597-26-9
Synonyms Rozerem, TAK-375, TAK375
SMILES CCC(=O)NCC[[email protected]@H]1CCC2=C1C3=C(C=C2)OCC3
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.
Targets
MT1 receptor MT receptor (chicken) MT2 receptor
14 pM(Ki)23.1 pM(Ki)112 pM(Ki)
In vitro (25°C) DMSO 52 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 52 mg/mL (200.5 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.57 mL 192.83 mL 385.65 mL
0.5 mM 7.71 mL 38.57 mL 77.13 mL
1 mM 3.86 mL 19.28 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL

*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.