Sitagliptin phosphate monohydrate

Catalog No. A10848

Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
Catalog Num A10848
M. Wt 523.3
Formula C16H15F6N5O.H3PO4.H2O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 654671-77-9
Synonyms Januvia, MK-0431
SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[[email protected]@H](CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O
Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
Targets
DPP-4 (Cell-free assay)
19 nM
In vitro (25°C) DMSO 100 mg/mL (191.08 mM)
Water 41 mg/mL (78.34 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.11 mL 95.55 mL 191.09 mL
0.5 mM 3.82 mL 19.11 mL 38.22 mL
1 mM 1.91 mL 9.55 mL 19.11 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

*The above data is based on the productmolecular weight 523.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.