SNS-032 (BMS-387032)

Catalog No. A10850

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Catalog Num A10850
M. Wt 380.5
Formula C17H24N4O2S2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 345627-80-7
Synonyms SNS032, BMS-387032, BMS387032
SMILES CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
Target Value
CDK9/CyclinTIC50: 4nM
CDK2/CyclinAIC50: 38nM
CDK2/CyclinEIC50: 48nM
CDK7/CyclinHIC50: 62nM
GSK-3αIC50: 230nM
CDK5/p35IC50: 340nM
CDK1/CyclinBIC50: 480nM
GSK-3βIC50: 660nM
CDK4/CyclinDIC50: 925nM
CDK6/CyclinDIC50: >1μM
In vitro (25°C) DMSO 76 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.28 mL 131.41 mL 262.81 mL
0.5 mM 5.26 mL 26.28 mL 52.56 mL
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.