StaurosporineCatalog No. A10864

Quick Overview

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
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Staurosporine

Staurosporine  Citations(2)
  • Jacobs CL,et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 29967496
  • Birte Plitzko,et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 29074620
  • Product Information
    Catalog Num A10864
    M. Wt 466.5
    Formula C28H26N4O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 62996-74-1
    Synonyms AM-2282, STS
    Chemical Name (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
    SMILES Code C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

    Biological activity
    Introduction
    Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
    Targets
    Target Value
    PKCαIC50: 2nM
    c-FgrIC50: 2nM
    phosphorylasekinaseIC50: 3nM
    PKCηIC50: 4nM
    PKCγIC50: 5nM
    S6kinaseIC50: 5nM
    v-SrcIC50: 6nM
    Cdc2IC50: 9nM
    Cdc2IC50: 9nM
    PKAIC50: 15nM
    SykIC50: 16nM
    PKGIC50: 18nM
    PKCδIC50: 20nM
    CaMKIIIC50: 20nM
    LynIC50: 20nM
    MLCKIC50: 21nM
    PKCεIC50: 73nM
    PKCζIC50: 1086nM
    Solubility
    Solubility (25C)* In vitro DMSO 4 mg/mL (8.57 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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