TGX-221

Catalog No. A10923

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Catalog Num A10923
M. Wt 364.4
Formula C21H24N4O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 663619-89-4
Synonyms TGX221
SMILES CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
Targets
Target Value
p110βIC50: 5nM
p110δIC50: 0.1μM
p110αIC50: 5μM
p110γIC50: >10μM
C2αIC50: >10μM
PI4KIC50: >10μM
AblIC50: >10μM
EGFRIC50: >10μM
FynIC50: >10μM
HER2IC50: >10μM
Insulin ReceptorIC50: >10μM
CaseinKinase2IC50: >10μM
CDK2/CyclinAIC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
p70S6KIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
CaMKIC50: >10μM
In vitro (25°C) DMSO 12 mg/mL (32.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.