Vinorelbine (Navelbine)Catalog No. A10976

Quick Overview

Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
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Vinorelbine (Navelbine)

Vinorelbine (Navelbine)  Citations(2)
  • Nicholas F. Dybdal-Hargreaves,et al. Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin, Oncotarget, 2018, Jan 19; 9(5): 5545-5561 29464017
  • APRIL L. RISINGER,et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. 26504006
  • Product Information
    Catalog Num A10976
    M. Wt 778.9
    Formula C45H54N4O8
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 71486-22-1
    Synonyms N/A
    Chemical Name 4-(acetyloxy)- 6,7-didehydro- 15-((2R,6R,8S)-4-ethyl- 1,3,6,7,8,9-hexahydro- 8-(methoxycarbonyl)- 2,6-methano- 2H-azecino(4,3-b)indol-8-yl)- 3-hydroxy- 16-methoxy- 1-methyl- methyl ester,
    SMILES Code CCC1=C[[email protected]]2C[[email protected]@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[[email protected]]78CCN9[[email protected]]7[[email protected]@](C=CC9)([[email protected]]([[email protected]@]([[email protected]@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC

    Biological activity
    Introduction
    Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
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