Foretinib (GSK1363089, XL880)Catalog No. A10998

Quick Overview

Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
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Foretinib (GSK1363089, XL880)

Foretinib (GSK1363089, XL880)  Citations(3)
  • Hayato Ogura,et al. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity, Sci Rep, 2017, 7: 5519 28717217
  • Fuse MJ,et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 28751539
  • Ryohei Katayama,et al. Cabozantinib overcomes crizotinib resistance in ROS1 fusion positive cancer, Clin Cancer Res. , 2015, Jan 1; 21(1): 166-174. 25351743
  • Product Information
    Catalog Num A10998
    M. Wt 632.7
    Formula C34H34F2N4O6
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 849217-64-7
    Synonyms GSK089, EXEL-2880
    Chemical Name N1’-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES Code COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

    Biological activity
    Introduction
    Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
    Targets
    Target Value
    MetIC50: 0.4nM
    KDRIC50: 0.86nM
    Tie-2IC50: 1.1nM
    VEGFR3/FLT4IC50: 2.8nM
    RONIC50: 3nM
    FLT3IC50: 3.6nM
    PDGFRαIC50: 3.6nM
    KitIC50: 6.7nM
    VEGFR1/FLT1IC50: 6.8nM
    PDGFRβIC50: 9.6nM
    FGFR1IC50: 660nM
    EGFRIC50: 2.99μM
    Solubility
    Solubility (25C) * In vitro DMSO 127 mg/mL (200.74 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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