Zibotentan (ZD4054)Catalog No. A11006

Quick Overview

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
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Zibotentan (ZD4054)

Zibotentan (ZD4054)  Citations(1)
  • Tony Ngo,et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 27992882
  • Product Information
    Catalog Num A11006
    M. Wt 424.4
    Formula C19H16N6O4S
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 186497-07-4
    Synonyms ZD-4054
    Chemical Name N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
    SMILES Code CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

    Biological activity
    Introduction
    Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
    Targets
    ET-A
    21 nM
    Solubility
    Solubility (25C) * In vitro DMSO 24 mg/mL (56.54 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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