ZM-447439

Catalog No. A11009

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
Catalog Num A11009
M. Wt 513.6
Formula C29H31N5O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 331771-20-1
Synonyms ZM447439
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
Targets
Target Value
AuroraAIC50: 110nM
AuroraBIC50: 130nM
LCKIC50: 880nM
SrcIC50: 1.03μM
MEK1IC50: 1.79μM
CDK1IC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
PLK1IC50: >10μM
Chk1IC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM
cFLT2IC50: >10μM
KDR2IC50: >10μM
ZAP70IC50: >10μM
FAKIC50: >10μM
In vitro (25°C) DMSO 103 mg/mL (200.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.