Quick Overview

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
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BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib)  Citations(7)
  • Nachi Namatame,et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141-35161 30416685
  • Jin H. Song,et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 30190422
  • Saijo A,et al. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells, Cancer Lett, 2018, May 1;421:17-27 29448000
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Pridham KJ,et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 29016844
  • Charles-Andr谷 Philip,et al. Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors, BMC Cancer, 2017, 17: 638 28886696
  • Rogers HA,et al. PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival., Clin Cancer Res., 2013, Dec 1;19(23):6450-60 24077346
  • Product Information
    Catalog Num A11016
    M. Wt 410.4
    Formula C18H21F3N6O2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 944396-07-0
    Synonyms N/A
    Chemical Name 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine
    SMILES Code C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

    Biological activity
    Introduction
    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
    Targets
    Target Value
    p110αIC50: 52nM
    p110δIC50: 116nM
    p110βIC50: 166nM
    p110γIC50: 262nM
    Vps34IC50: 2.4μM
    mTORIC50: 4.6μM
    DNA-PKIC50: >5μM
    PI4KβIC50: >25μM
    Solubility
    Solubility (25C) * In vitro DMSO 82 mg/mL (199.8 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 2 mg/mL (4.87 mM)
    In vivo 0.5% CMC Na 6 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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    High Purity Kinase Inhibitors on Signaling Pathways

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