NVP-AEW541Catalog No. A11021

Quick Overview

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
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NVP-AEW541

NVP-AEW541  Citations(1)
  • Tsushima H,et al. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis, Autoimmunity, 2017, Aug;50(5):329-335 28682648
  • Product Information
    Catalog Num A11021
    M. Wt 439.6
    Formula C27H29N5O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 475489-16-8
    Synonyms AEW541
    Chemical Name 7-​[cis-​3-​(1-​azetidinylmethyl)cyclobutyl]-​5-​[3-​(phenylmethoxy)phenyl]-​7H-​pyrrolo[2,​3-​d]pyrimidin-​4-​amine
    SMILES Code C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

    Biological activity
    Introduction
    NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
    Solubility
    Solubility (25C) * In vitro DMSO 88 mg/mL (200.2 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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    High Purity Kinase Inhibitors on Signaling Pathways

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