AG-1478 (Tyrphostin AG-1478) Catalog No. A11022

Quick Overview

AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
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AG-1478 (Tyrphostin AG-1478)

AG-1478 (Tyrphostin AG-1478)   Citations(2)
  • Khattab M,et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 29629773
  • Muhammad Khattab,et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 29176733
  • Product Information
    Catalog Num A11022
    M. Wt 315.8
    Formula C16H14ClN3O2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 153436-53-4
    Synonyms AG1478, AG 1478
    Chemical Name N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine
    SMILES Code COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

    Biological activity
    AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
    EGFR (Cell-free assay) HER2 (Cell-free assay) PDGFR (Cell-free assay)
    3 nM>100 μM>100 μM
    Solubility (25C) * In vitro DMSO 25 mg/mL (79.17 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 13 mg/mL (41.17 mM)
    In vivo 15% Captisol 15% Captisol
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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