OSI-906Catalog No. A11053

Quick Overview

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
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OSI-906

OSI-906  Citations(3)
  • Nakamura T,et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 29583066
  • Tzeng SF,et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 29906246
  • Takata N,et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 26956358
  • Product Information
    Catalog Num A11053
    M. Wt 421.5
    Formula C26H23N5O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 867160-71-2
    Synonyms OSI906, linsitinib
    Chemical Name cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol
    SMILES Code CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

    Biological activity
    Introduction
    OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
    Targets
    Target Value
    IGF-1RIC50: 35nM
    Insulin ReceptorIC50: 75nM
    IRRIC50: 75nM
    AblIC50: >10μM
    ALKIC50: >10μM
    BTKIC50: >10μM
    EGFRIC50: >10μM
    EphA1IC50: >10μM
    EphB1IC50: >10μM
    FESIC50: >10μM
    FGFR1IC50: >10μM
    FGFR2IC50: >10μM
    FynIC50: >10μM
    PKAIC50: >10μM
    PKCαIC50: >10μM
    ROCK1IC50: >10μM
    IRAK4IC50: >10μM
    JAK2IC50: >10μM
    KDRIC50: >10μM
    LCKIC50: >10μM
    LynAIC50: >10μM
    LynBIC50: >10μM
    MetIC50: >10μM
    TrkAIC50: >10μM
    PDGFRαIC50: >10μM
    PDGFRβIC50: >10μM
    FAKIC50: >10μM
    BRKIC50: >10μM
    RETIC50: >10μM
    Pim1IC50: >10μM
    CDK1IC50: >10μM
    DYRK2IC50: >10μM
    SrcIC50: >10μM
    TekIC50: >10μM
    MEK1IC50: >10μM
    Akt1IC50: >10μM
    Akt2IC50: >10μM
    AuroraAIC50: >10μM
    AuroraBIC50: >10μM
    PDK-1IC50: >10μM
    PLK1IC50: >10μM
    p38αIC50: >10μM
    ERK1IC50: >10μM
    GSK-3αIC50: >10μM
    p70S6KIC50: >10μM
    Solubility
    Solubility (25C) * In vitro DMSO 84 mg/mL (199.29 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

    >>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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