AZD4547Catalog No. A11075

Quick Overview

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
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AZD4547

AZD4547  Citations(2)
  • Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
  • Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887
  • Product Information
    Catalog Num A11075
    M. Wt 463.6
    Formula C26H33N5O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1035270-39-3
    Synonyms AZD-4547
    SMILES Code C[[email protected]@H]1CN(C[[email protected]@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

    Biological activity
    Introduction
    AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
    Targets
    Target Value
    FGFR1IC50: 0.2nM
    FGFR3IC50: 1.8nM
    FGFR2IC50: 2.5nM
    KDRIC50: 24nM
    FGFR4IC50: 165nM
    IGFRIC50: 581nM
    AxlIC50: >2μM
    CDK2IC50: >10μM
    FAKIC50: >10μM
    ROCK2IC50: >50μM
    Akt1IC50: >100μM
    ALK1IC50: >100μM
    p38IC50: >100μM
    PI3KαIC50: >100μM
    Solubility
    Solubility (25C) * In vitro DMSO 92 mg/mL (198.45 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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