PH-797804

Catalog No. A11078

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
  • Yuho Ito, .et al. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway, Biosci Biotechnol Biochem, 2015, 79(11):1794-801 PMID: 26057585
Catalog Num A11078
M. Wt 477.2
Formula C22H19BrF2N2O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 586379-66-0
Synonyms PH797804
SMILES CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C
PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
Targets
p38α (Cell-free assay) p38β (Cell-free assay)
26 nM102 nM
In vitro (25°C) DMSO 96 mg/mL (201.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (14.66 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.96 mL 104.78 mL 209.56 mL
0.5 mM 4.19 mL 20.96 mL 41.91 mL
1 mM 2.1 mL 10.48 mL 20.96 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 477.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.