Dinaciclib (SCH 727965)Catalog No. A11129

Quick Overview

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
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Dinaciclib (SCH 727965)

Dinaciclib (SCH 727965)  Citations(1)
  • Washio I,et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 29246888
  • Product Information
    Catalog Num A11129
    M. Wt 396.5
    Formula C21H28N6O2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 779353-01-4
    Synonyms SCH727965, SCH-727965
    Chemical Name (S)-3-(((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide?
    SMILES Code CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO

    Biological activity
    Introduction
    Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
    Targets
    CDK2 (Cell-free assay) CDK5 (Cell-free assay) CDK1 (Cell-free assay) CDK9 (Cell-free assay)
    1 nM1 nM3 nM4 nM
    Solubility
    Solubility (25C) * In vitro DMSO 26 mg/mL heating (65.57 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 8 mg/mL heating (20.17 mM)
    In vivo 15% Captisol 6 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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