Dinaciclib (SCH 727965)

Catalog No. A11129

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
  • Washio I, .et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888
Catalog Num A11129
M. Wt 396.5
Formula C21H28N6O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 779353-01-4
Synonyms SCH727965, SCH-727965
SMILES CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
Targets
CDK2 (Cell-free assay) CDK5 (Cell-free assay) CDK1 (Cell-free assay) CDK9 (Cell-free assay)
1 nM1 nM3 nM4 nM
In vitro (25°C) DMSO 26 mg/mL heating (65.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL heating (20.17 mM)
In vivo 15% Captisol 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.22 mL 126.1 mL 252.21 mL
0.5 mM 5.04 mL 25.22 mL 50.44 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.