GW4064Catalog No. A11141

Quick Overview

GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
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GW4064

GW4064  Citations(1)
  • Takae K,et al. Evidence for the involvement of FXR signaling in ovarian granulosa cell function, J Reprod Dev, 2018, Nov 16 30449821
  • Product Information
    Catalog Num A11141
    M. Wt 542.8
    Formula C28H22Cl3NO4
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 278779-30-9
    Synonyms GW-4064
    Chemical Name 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
    SMILES Code CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl

    Biological activity
    Introduction
    GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
    Targets
    FXR (CV1)
    65 nM(EC50)
    Solubility
    Solubility (25C) * In vitro DMSO 109 mg/mL (200.79 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 0.5% methylcellulose 11 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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