RS-127445Catalog No. A11165

Quick Overview

RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.

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RS-127445

RS-127445  Citations(1)
  • Takeshi Takayanagi,et al. Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide, Fujita Medical Journal, 2015, 1(1), 1-5, 2015
  • Product Information
    Catalog Num A11165
    M. Wt 281.33
    Formula C17H16FN3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 199864-87-4
    Synonyms RS127445, MT 500, RS127,445
    Chemical Name 4-(4-fluoro-1-naphthyl)-6-isopropylpyrimidin-2-amine
    SMILES Code CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N.Cl

    Biological activity
    Introduction

    RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.

    Targets
    5-HT2B 5-HT2B
    10.4(pIC50)9.5(pKi)
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