AZ 3146Catalog No. A11170

Quick Overview

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

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AZ 3146

AZ 3146  Citations(2)
  • Kakihana A, .et al. Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint, FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
  • Suzuki M, .et al. Effect of MPS1 Inhibition on Genotoxic Stress Responses in Murine Tumour Cells, Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789
  • Product Information
    Catalog Num A11170
    M. Wt 452.55
    Formula C24H32N6O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1124329-14-1
    Synonyms AZ-3146
    SMILES Code CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC

    Biological activity
    Introduction

    AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

    Targets
    Mps1
    ~35 nM
    Solubility
    Solubility (25C)* In vitro DMSO 28 mg/mL (61.87 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 91 mg/mL (201.08 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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    High Purity Kinase Inhibitors on Signaling Pathways

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