LY-411575Catalog No. A11176

Quick Overview

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

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LY-411575  Citations(3)
  • Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
  • Product Information
    Catalog Num A11176
    M. Wt 479.48
    Formula C26H23F2N3O4
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 209984-57-6
    Synonyms LY411575
    SMILES Code C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O

    Biological activity

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
    0.078 nM0.082 nM0.39 nM
    Solubility (25C) * In vitro DMSO 95 mg/mL (198.13 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 95 mg/mL (198.13 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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