DCC-2036 (Rebastinib)Catalog No. A11200

Quick Overview

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

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DCC-2036 (Rebastinib)

DCC-2036 (Rebastinib)  Citations(1)
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Product Information
    Catalog Num A11200
    M. Wt 553.59
    Formula C30H28FN7O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1020172-07-9
    Synonyms DCC2036
    Chemical Name N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea
    SMILES Code CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5

    Biological activity
    Introduction

    DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

    Targets
    Target Value
    u-Abl1(native)IC50: 0.75nM
    Abl1(H396P)IC50: 1.4nM
    p-Abl1(native)IC50: 2nM
    FLT3IC50: 2nM
    p-Abl1(T315I)IC50: 4nM
    KDRIC50: 4nM
    u-Abl1(T315I)IC50: 5nM
    Tie-2IC50: 6nM
    LynIC50: 29nM
    SrcIC50: 34nM
    FGRIC50: 38nM
    HckIC50: 40nM
    PDGFRαIC50: 70nM
    PDGFRβIC50: 113nM
    c-KitIC50: 481nM
    AuroraAIC50: >5μM
    CDK2/CyclinDIC50: >5μM
    Solubility
    Solubility (25C) * In vitro DMSO 111 mg/mL (200.5 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 16 mg/mL (28.9 mM)
    In vivo 0.5% CMC/0.25% Tween 80 16 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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