GW3965 HClCatalog No. A11204

Quick Overview

GW3965 HCl is a selective and orally active liver X receptor (LXR) full agonist.
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GW3965 HCl

GW3965 HCl  Citations(3)
  • Moh芍csik P,et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 29253128
  • Pencheva N,et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 24581497
  • Bin Dong,et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. 23427282
  • Product Information
    Catalog Num A11204
    M. Wt 618.51
    Formula C33H31ClF3NO3.HCl
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 405911-17-3
    Synonyms GW-3965
    Chemical Name (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid hydrochloride
    SMILES Code C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

    Biological activity
    GW3965 HCl is a selective and orally active liver X receptor (LXR) full agonist.
    hLXRβ (Cell-free assay) LXRα/SRC1?LiSA (Cell-free assay) hLXRα (Cell-free assay)
    30 nM(EC50)125 nM(EC50)190 nM(EC50)
    Solubility (25C)* In vitro DMSO 124 mg/mL (200.48 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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