BMY 7378

Catalog No. A11208

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
Catalog Num A11208
M. Wt 458.42
Formula C22H31N3O3.2HCl
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 21102-95-4
Synonyms BMY7378, BMY-7378
SMILES COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl
BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
Targets
Target Value
5-HT1ApIC50: 8.3
α1D-adrenoceptorpki: 8.2
DopamineD2receptorpIC50: 7.4
α2C-adrenoceptorpki: 6.54
5-HT1CpIC50: 6.4
5-HT1DpIC50: 5.9
H1receptorpIC50: 5.7
5-HT2pIC50: 5.5
H2receptorpIC50: 5.3
α2-adrenoceptor pIC50: 5.1
β1-adrenoceptor pIC50: 5.1
DopamineD1receptorpIC50: 5
NicotinicreceptorpIC50: 4.9
β2-adrenoceptor pIC50: <5.0
5-HT3pIC50: <5.0
H3receptorpIC50: <5.0
GABAAreceptorpIC50: <5.0
GABABreceptorpIC50: <5.0
MuscarinicM1receptorpIC50: <5.0
MuscarinicM2receptorpIC50: <5.0
MuscarinicM3receptorpIC50: <5.0
NMDAreceptorpIC50: <5.0
AT1receptorpIC50: <5.0
AT2receptorpIC50: <5.0
EndothelinReceptorpIC50: <5.0
AdenosineA1receptorpIC50: <5.0
AdenosineA2receptorpIC50: <5.0
In vitro (25°C) DMSO 81 mg/mL (176.69 mM)
Water 81 mg/mL (176.69 mM)
Ethanol 18 mg/mL (39.26 mM)
In vivo Saline 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.07 mL 218.14 mL
0.5 mM 4.36 mL 21.81 mL 43.63 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

*The above data is based on the productmolecular weight 458.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.