Kenpaullone

Catalog No. A11220

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
Catalog Num A11220
M. Wt 327.2
Formula C16H11BrN2O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 142273-20-9
Synonyms N/A
SMILES C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
Targets
Target Value
GSK-3βIC50: 0.23μM
CDK1/CyclinBIC50: 0.4μM
CDK2/CyclinAIC50: 0.68μM
CDK5/p35IC50: 0.85μM
CDK2/CyclinEIC50: 7.5μM
ERK2IC50: 9μM
c-SrcIC50: 15μM
CaseinKinase2IC50: 20μM
ERK1IC50: 20μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.56 mL 152.81 mL 305.62 mL
0.5 mM 6.11 mL 30.56 mL 61.12 mL
1 mM 3.06 mL 15.28 mL 30.56 mL
5 mM 0.61 mL 3.06 mL 6.11 mL

*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.