KenpaulloneCatalog No. A11220

Quick Overview

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
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Kenpaullone

Product Information
Catalog Num A11220
M. Wt 327.2
Formula C16H11BrN2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 142273-20-9
Synonyms N/A
SMILES Code C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

Biological activity
Introduction
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
Targets
Target Value
GSK-3βIC50: 0.23μM
CDK1/CyclinBIC50: 0.4μM
CDK2/CyclinAIC50: 0.68μM
CDK5/p35IC50: 0.85μM
CDK2/CyclinEIC50: 7.5μM
ERK2IC50: 9μM
c-SrcIC50: 15μM
CaseinKinase2IC50: 20μM
ERK1IC50: 20μM
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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