FG-4592 (Roxadustat)Catalog No. A11237

Quick Overview

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
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FG-4592 (Roxadustat)

FG-4592 (Roxadustat)  Citations(3)
  • Hideaki Nakamura,et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 29466367
  • Singh C,et al. 3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis, Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 30025089
  • George Hoppe,et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity, Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516-E2525 27091985
  • Product Information
    Catalog Num A11237
    M. Wt 352.3
    Formula C19H16N2O5
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 808118-40-3
    Synonyms FG4592, ASP1517
    Chemical Name 2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid
    SMILES Code CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O

    Biological activity
    Introduction
    FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
    Targets
    HIF α prolyl hydroxylase (Cell-free assay)
    Solubility
    Solubility (25C)* In vitro DMSO 70 mg/mL (198.67 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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