FG-4592 (Roxadustat)Catalog No. A11237

Quick Overview

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Products are for laboratory research use only. Not for human use. We do not sell to patients.

FG-4592 (Roxadustat) Citations(3)

Hideaki Nakamura,et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 29466367

Singh C,et al. 3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis, Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 30025089

George Hoppe,et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity, Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516-E2525 27091985

Product Information

Catalog Num	A11237
M. Wt	352.3
Formula	C19H16N2O5
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	808118-40-3
Synonyms	FG4592, ASP1517
Chemical Name	2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid
SMILES Code	CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O

Biological activity

Introduction

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Targets

HIF α prolyl hydroxylase (Cell-free assay)

Solubility

Solubility (25C)*	In vitro	DMSO	70 mg/mL (198.67 mM)
		Water	<1 mg/mL (<1 mM)
		Ethanol	<1 mg/mL (<1 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Return Policy

Contact information

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