MLN4924 (Pevonedistat)Catalog No. A11260

Quick Overview

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
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MLN4924 (Pevonedistat)

MLN4924 (Pevonedistat)  Citations(3)
  • Stephan Riesenberg,et al. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells, Nat Commun, 2018, 9: 2164 29867139
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Richard J. Kraus,et al. Hypoxia-inducible factor-1汐 plays roles in Epstein-Barr virus*s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter, PLoS Pathog, 2017, Jun; 13(6): e1006404 28617871
  • Product Information
    Catalog Num A11260
    M. Wt 443.5
    Formula C21H25N5O4S
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 905579-51-3
    Synonyms MLN-4924
    Chemical Name Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester
    SMILES Code C1CC2=CC=CC=C2[[email protected]]1NC3=NC=NC4=C3C=CN4[[email protected]@H]5C[[email protected]]([[email protected]](C5)O)COS(=O)(=O)N

    Biological activity
    Introduction
    NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
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