RefametinibCatalog No. A11264

Quick Overview

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
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Refametinib

Product Information
Catalog Num A11264
M. Wt 572.34
Formula C19H20F3IN2O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923032-37-5
Synonyms BAY 869766,RDEA119, Bay 86-9766
SMILES Code COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[[email protected]@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F

Biological activity
Introduction
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
Targets
MEK1 MEK2
19 nM47 nM
Solubility
Solubility (25C)* In vitro DMSO 100 mg/mL (174.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (174.72 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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