Ambrisentan (BSF 208075)Catalog No. A11291

Quick Overview

Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
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Ambrisentan (BSF 208075)

Ambrisentan (BSF 208075)  Citations(2)
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
  • Toshiaki Okamoto, .et al. Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model, World J Hepatol, 2016, Aug 8; 8(22): 933-941 PMID: 27574547
  • Product Information
    Catalog Num A11291
    M. Wt 378.4
    Formula C22H22N2O4
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 177036-94-1
    Synonyms BSF 208075,
    SMILES Code CC1=CC(=NC(=N1)O[[email protected]](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

    Biological activity
    Introduction
    Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
    Targets
    ET-A
    Solubility
    Solubility (25C)* In vitro DMSO 76 mg/mL (200.83 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 22 mg/mL (58.13 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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