Ambrisentan (BSF 208075)

Catalog No. A11291

Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
  • Toshiaki Okamoto, .et al. Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model, World J Hepatol, 2016, Aug 8; 8(22): 933-941 PMID: 27574547
Catalog Num A11291
M. Wt 378.4
Formula C22H22N2O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 177036-94-1
Synonyms BSF 208075,
SMILES CC1=CC(=NC(=N1)O[[email protected]](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
Targets
ET-A
In vitro DMSO 76 mg/mL (200.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol 22 mg/mL (58.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.43 mL 132.14 mL 264.27 mL
0.5 mM 5.29 mL 26.43 mL 52.85 mL
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL

*The above data is based on the productmolecular weight 378.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.