CZC24832Catalog No. A11363

Quick Overview

CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).
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CZC24832

CZC24832  Citations(1)
  • Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639-19655 PMID: 28974577
  • Product Information
    Catalog Num A11363
    M. Wt 364.4
    Formula C15H17FN6O2S
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1159824-67-5
    Synonyms CZC 24832, CZC-24832
    SMILES Code CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)F

    Biological activity
    Introduction
    CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).
    Targets
    PI3Kγ PI3Kβ PI3Kδ
    27 nM1.1 μM8.2 μM
    Solubility
    Solubility (25C) * In vitro DMSO 5 mg/mL heating (13.72 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 0.5% CMC 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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