Dovitinib (TKI-258)

Catalog No. A11411

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
Catalog Num A11411
M. Wt 392.4
Formula C21H21FN6O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 405169-16-6
Synonyms CHIR-258, CHIR258, TKI258
SMILES CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C\4/C(=C5C(=NC4=O)C=CC=C5F)N)/N3
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
Targets
Target Value
FLT3IC50: 1nM
c-KitIC50: 2nM
FGFR1IC50: 8nM
VEGFR3/FLT4IC50: 8nM
FGFR3IC50: 9nM
VEGFR1/FLT1IC50: 10nM
VEGFR2/Flk1IC50: 13nM
PDGFRβIC50: 27nM
CSF-1R/c-FmsIC50: 36nM
PDGFRαIC50: 210nM
Insulin ReceptorIC50: 2μM
EGFRIC50: 2μM
c-MetIC50: >3μM
EphA2IC50: 4μM
Tie-2IC50: 4μM
IGF-1RIC50: >10μM
HER2IC50: >10μM
In vitro (25°C) DMSO 30 mg/mL (76.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.42 mL 254.84 mL
0.5 mM 5.1 mL 25.48 mL 50.97 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.