GDC-0349

Catalog No. A11443

GDC-0349 is under evaluating the Safety and Tolerability in Patients with locally advanced or metastatic solid tumors or non hodgkin's lymphoma.
Catalog Num A11443
M. Wt 452.6
Formula C24H32N6O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1207360-89-1
Synonyms GDC 0349, RG7603
SMILES CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[[email protected]@H]5C
GDC-0349 is under evaluating the Safety and Tolerability in Patients with locally advanced or metastatic solid tumors or non hodgkin's lymphoma.
Targets
mTOR PI3Kα
3.8 nM(Ki)~3 μM(Ki)
In vitro DMSO 91 mg/mL (201.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (13.25 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.09 mL 110.47 mL 220.95 mL
0.5 mM 4.42 mL 22.09 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.09 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.