MEK162 (ARRY-438162, Binimetinib)

Catalog No. A11493

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
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Catalog Num A11493
M. Wt 440.0
Formula C17H15BrF2N4O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 606143-89-9
Synonyms ARRY-162, MEK-162, MEK 162
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
Targets
MEK
12 nM
In vitro (25°C) DMSO 88 mg/mL (199.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.73 mL 113.64 mL 227.27 mL
0.5 mM 4.55 mL 22.73 mL 45.45 mL
1 mM 2.27 mL 11.36 mL 22.73 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.