Sotrastaurin (AEB071)

Catalog No. A11554

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Catalog Num A11554
M. Wt 438.5
Formula C25H22N6O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 425637-18-9
Synonyms AEB 071, AEB-071
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Targets
Target Value
PKCθki: 0.22nM
PKCβ1ki: 0.64nM
PKCαki: 0.95nM
PKCηki: 1.8nM
PKCδki: 2.1nM
PKCεki: 3.2nM
In vitro DMSO 87 mg/mL (198.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.56 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.03 mL 228.05 mL
0.5 mM 4.56 mL 22.81 mL 45.61 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.