Tariquidar (XR9576)Catalog No. A11584

Quick Overview

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
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Tariquidar (XR9576)

Tariquidar (XR9576)  Citations(3)
  • Sugisawa N,et al. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell, Mol Pharm, 2018, Sep 4;15(9):4021-4030 30052463
  • Samy A. F. Morad,et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 28189725
  • Debora Petroni,et al. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein, Mol Imaging Biol, 2016, Dec;18(6):916-923 27234445
  • Product Information
    Catalog Num A11584
    M. Wt 646.73
    Formula C38H38N4O6
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 206873-63-4
    Synonyms XR 9576??XR9576??D06008
    Chemical Name N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
    SMILES Code COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC

    Biological activity
    Introduction
    Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
    Targets
    P-gp (CHrB30 cells)
    5.1 nM(Kd)
    Solubility
    Solubility (25C) * In vitro DMSO 52 mg/mL (80.4 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

    >>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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