ACY-1215 (Rocilinostat)

Catalog No. A11940

ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
Catalog Num A11940
M. Wt 433.5
Formula C24H27N5O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1316214-52-4
Synonyms ACY1215
SMILES C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
Targets
Target Value
HDAC6IC50: 4.7nM
HDAC2IC50: 48nM
HDAC3IC50: 51nM
HDAC1IC50: 58nM
HDAC8IC50: 100nM
HDAC7IC50: 1.4μM
HDAC5IC50: 5μM
HDAC4IC50: 7μM
HDAC9IC50: >10μM
HDAC11IC50: >10μM
Sirtuin1IC50: >10μM
Sirtuin2IC50: >10μM
In vitro (25°C) DMSO 86 mg/mL (198.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.07 mL 115.34 mL 230.68 mL
0.5 mM 4.61 mL 23.07 mL 46.14 mL
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL

*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.