Ki16198

Catalog No. A11966

Ki16198 is a potent LPA receptor antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively.

Technical details

Catalog Num	A11966
M. Wt	488.98
Formula	C24H25ClN2O5S
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	355025-13-7
Synonyms	Ki-16198
SMILES	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)OC

Biological Activity

Ki16198 is a potent LPA receptor antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively.

Targets

LPA1	LPA3
0.34 μM(Ki)	0.93 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	86 mg/mL (175.87 mM)
	Water	Insoluble
	Ethanol	32 mg/mL (65.44 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.45 mL	102.25 mL	204.51 mL
0.5 mM	4.09 mL	20.45 mL	40.9 mL
1 mM	2.05 mL	10.23 mL	20.45 mL
5 mM	0.41 mL	2.05 mL	4.09 mL

*The above data is based on the productmolecular weight 488.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.