Bedaquiline (TMC-207)Catalog No. A12327

Quick Overview

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
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Bedaquiline (TMC-207)

Bedaquiline (TMC-207)  Citations(8)
  • Belosludtsev KN, .et al. Effect of bedaquiline on the functions of rat liver mitochondria, Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Belosludtsev KN, .et al. Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes, Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
  • Wu X, .et al. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism, Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
  • Jichan Jang, .et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
  • Marco Fiorillo, .et al. Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs), Aging (Albany NY), 2016, Aug; 8(8): 1593每1606 PMID: 27344270
  • Alvaro A. Ordonez, .et al. Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice, Antimicrob Agents Chemother, 2015, Jan; 59(1): 642每649. PMID: 25403669
  • Ke Liu, .et al. Bedaquiline Metabolism: Enzymes and Novel Metabolites, Drug Metab Dispos., 2014, May; 42(5): 863每866 PMID: 24513655
  • Product Information
    Catalog Num A12327
    M. Wt 555.5
    Formula C32H31BrN2O2
    Solubility DMSO
    Purity >97%
    Storage at -20°C 3 years Powder
    CAS No. 843663-66-1
    Synonyms Sirturo, TMC2N/A7, R2N/A791N/A
    Chemical Name (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol
    SMILES Code

    Biological activity
    Introduction
    TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
    Return Policy Contact information
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