VS-5584

Catalog No. A12480

VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Catalog Num A12480
M. Wt 354.41
Formula C17H22N8O
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 1246560-33-7
Synonyms SB2343, VS5584, SB-2343, SB 2343
SMILES CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N
VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Targets
PI3Kα PI3Kδ PI3Kγ mTOR PI3Kβ
2.6 nM2.7 nM3.0 nM3.4 nM21 nM
In vitro (25°C) DMSO 70 mg/mL (197.51 mM)
Water Insoluble
Ethanol 3 mg/mL (8.46 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.22 mL 141.08 mL 282.16 mL
0.5 mM 5.64 mL 28.22 mL 56.43 mL
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL

*The above data is based on the productmolecular weight 354.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.