T0901317

Catalog No. A12652

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively

Product Citations

Tian Yongsong, .et al. Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317, J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593

Technical details

Catalog Num	A12652
M. Wt	481.33
Formula	C17H12F9NO3S
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	293754-55-9
Synonyms
SMILES	C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

Biological Activity

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively

Targets

LXR	FXR
50 nM(EC50)	5 μM(EC50)

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (182.82 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (182.82 mM)
In vivo	2% DMSO+35% PEG 300+5% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.78 mL	103.88 mL	207.76 mL
0.5 mM	4.16 mL	20.78 mL	41.55 mL
1 mM	2.08 mL	10.39 mL	20.78 mL
5 mM	0.42 mL	2.08 mL	4.16 mL

*The above data is based on the productmolecular weight 481.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience