PJ 34 hydrochloride

Catalog No. A12665

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).

Product Citations

Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104

Technical details

Catalog Num	A12665
M. Wt	331.8
Formula	C17H17N3O2.HCl
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	344458-15-7
Synonyms	PJ34, PJ-34
SMILES	CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl

Biological Activity

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).

Solubility *

In vitro (25°C)	DMSO	57 mg/mL (171.79 mM)
	Water	57 mg/mL (171.79 mM)
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.14 mL	150.69 mL	301.39 mL
0.5 mM	6.03 mL	30.14 mL	60.28 mL
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.6 mL	3.01 mL	6.03 mL

*The above data is based on the productmolecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.