NVP-BAW2881

Catalog No. A12693

NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.

Technical details

Catalog Num	A12693
M. Wt	424.1147
Formula	C22H15F3N4O2
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	861875-60-7
Synonyms	BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881
SMILES	O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3

Biological Activity

NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.

Targets

Target	Value
TIE-2
hVEGFR2	IC50: 9nM
C-Raf-1	IC50: 24nM
B-RAFV599E	IC50: 76nM
c-Abl	IC50: 99nM
mVEGF2	IC50: 165nM
RET	IC50: 410nM
hVEGFR3	IC50: 420nM
hVEGFR1	IC50: 820nM
c-KIT	IC50: 2.5μM

Solubility *

In vitro	DMSO	76 mg/mL (179.08 mM)
	Water	Insoluble
	Ethanol	18 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.58 mL	117.89 mL	235.79 mL
0.5 mM	4.72 mL	23.58 mL	47.16 mL
1 mM	2.36 mL	11.79 mL	23.58 mL
5 mM	0.47 mL	2.36 mL	4.72 mL

*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.