(+)-JQ1

Catalog No. A12729

(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
  • A Carrer, .et al. Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis, Cancer Discov, 2019, Jan 9. pii: CD-18-0567 PMID: 30626590
  • Clocchiatti A, .et al. Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation, J Clin Invest, 2018, Dec 3;128(12):5531-5548 PMID: 30395538
Catalog Num A12729
M. Wt 456.99
Formula C23H25ClN4O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1268524-70-4
Synonyms N/A
SMILES CC1=C(SC2=C1C(=N[[email protected]](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
In vitro DMSO 91 mg/mL (199.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol 91 mg/mL (199.12 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.88 mL 109.41 mL 218.82 mL
0.5 mM 4.38 mL 21.88 mL 43.76 mL
1 mM 2.19 mL 10.94 mL 21.88 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.